儿童骨龄评估与终高预测方法初探

时间:2024-07-05 10:54:31 药学毕业论文 我要投稿
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儿童骨龄评估与终高预测方法初探

作者:王秀民,何美朵,王伟,王德芬
【关键词】 骨龄评估
 【摘要】 目的 比较四种常用的骨龄评估法(BP、CHN、TW2、TW3)对骨龄评估结果的差异性;并比较用其对应的成人身高预测PAH法(BP、CHN、TW2-叶氏、TW3)预测不同病种患儿成人身高结果与实获终身高(NAH)的差异性。方法 身高测量用墙式测高器,手及腕部骨龄X线片投照按标准技术,骨龄评估:使用上海瑞金医院放射科设计的TW2、CHN骨龄评分软件及GP图谱,TW3根据TW2也用计算机辅助评估,用SPSS 10.0软件,计量资料以(x±s)表示,做单因素方差分析(ANOVA),组间差异用LSD方法分析。结果 在各年龄四种骨龄评估法(GP、CHN、TW2、TW3)结果差异无显著性(P>0.05);四种方法(BP、TW2-叶氏、CHN、TW3)预测终身高:BP法与预测终身高有正负相关即不同正相关性(R=0.95,P≤0.01),TW3与终身高也有正相关性R=0.923,P<0.01,如将患者分组,矮小组:TW2与NAH有差异(F=4.35,P=0.039),NAH与BP和CHN有相关性(R=0.918,P≤0.001),早熟组:三种方法(BP,CHN,TW2-叶氏),与NAH差异无显著性,相关系数分别为R=0.981,P<0.01,R=0.982,P<0.01,R=0.988,P≤0.01;TS组:BP与NAH差异无显著性(R=0.956,P<0.05),CHN与NAH不相关(R=0.623,P<0.05)。结论 (1)骨龄评估在小年龄(≤10岁),TW3与GP方法最接近。在大年龄评估中四种方法均可采用。(2)采用骨龄预测终身高TW3和BP法最接近NAH,但在不同疾病BP法更接近NAH。
  【关键词】 骨龄评估;近似终身高;预测终身高

  Methods of childrens bone age assessment and prediction of adult height
  【Abstract】 Objective To compare the different results of four common methods of bone age estimation (GP, CHN, TW2, TW3),and compare the differences between NAH and the predictive height by using the method of PAH (BP, CHN, TW2-Ye, TW3).Methods The heights were measured by instruments, and bone age of hand and wrist by X-ray according to standard technology. Bone age estimations were performed by using TW2, CHN bone age estimation software and GP map desired by Radiological Department of Shanghai Ruijin Hospital.TW3 estimation was done according to TW2 with computer assisting. Results was presented by χ2x±s. The software of SPSS 10.0 was used to statistically analysed with method of ANOVA. The differences among the groups were analysed by using the method of LSD. Results At different ages, the results of four methods of bone age estimation (GP, CHN, TW2, TW3) had no difference (P>0.05). BP method had positive correlation with predictive height (R=0.95,P≤0.01) and so was method of TW3 and predictive height (R=0.923, P≤0.01). Conclusion (1) At younger age (≤10 years old), the results of TW3 and GP are the closest to NAH. At elder age, we can use all the four methods to estimate the bone age. (2) For predicting height with bone age, the results of TW3 and BP are the closest to the NAH, but BP is closer to NAH if the child has any endocrine problems.
  【Key words】 bone age assessment;near adult height;prediction of adult height
  骨龄评估是评价儿童生长发育的重要内容,它能较准确地反映机体的发育水平和成熟程度,骨龄评估既有助于某些疾病的诊断,亦能指导儿童内分泌疾病某些药物的临床应用和成人身高预测。
  目前国内外常用的骨龄评估法有Greulich-Pyle手腕骨龄图谱法,Tanner-Whiterhouse手腕骨龄评分法(TW2),中国人骨(手腕)成熟度评分法,近来又推出TW3骨龄评估法,以骨龄预测终身高有相应的BP、TW2-叶氏、CHN及TW3方法。本文试以GP骨龄图谱及其骨龄作为标准[1],比较用其他三种方法对其骨龄再评估的方法差异性。此外又对三种常见内分泌疾病随访有近似成人终身高(NAH)者,比较以不同方法骨龄评估及其相应的终身高预测(PHA)法所测结果与NAH的差异性。
  1 资料与方法
  1.1 一般资料 GP图谱中骨龄自出生至18~19岁共47张骨龄图谱(男26例,女21例),另有男10例,女10例在上海瑞金医院儿科内分泌随访的儿童(其中矮小组10例,性早熟组5例,Turner综合征组5例),经随访已获实际近似终身高者;实际近似终身高(ANH)的确定:随访时上一年身高增长1.5cm和(或)骨龄达15岁(女)或16岁(男),终访时青春发育已达Tanner Ⅳ~Ⅴ期。
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