XRCC 2 基因多态性与非小细胞肺癌易感性的关系

XRCC 2 基因多态性与非小细胞肺癌易感性的关系

作者：王瑞，曾辉，李琰，王娜，张健慧，张金文，王伟，刘俊峰
【关键词】 非小细胞肺癌；XRCC,2基因；易感性；遗传多态性
　　Association between gene polymorphism of XRCC 2 and susceptibility of nonsmall cell lung cancers
　　1Department of Thoracic Surgery, Fourth Affiliated Hospital, Hebei Medical University, 2Laboratory of Molecular Biology, Hebei Cancer Institute, Shijiazhuang 050011, China, 3National Center for AIDS Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China, 4Operation Room, Thoracic Hospital of Hebei Province, Shijiazhuang 050011, China, 5Department of Surgery, Chengan County Hospital of Hebei Province, Handan 056700, China
　　【Abstract】 AIM: To observe the association between the risk of nonsmall cell lung cancers and polymorphism and gene frequency of XRCC 2 C41657T and G4234C in north Chinese Han population. METHODS: The single nucleotide polymorphisms (SNPs) of the C41657T and G4234C in the XRCC 2 gene were genotyped by PCRRFLP analysis in 226 nonsmall cell lung cancer patients and 300 healthy controls. RESULTS: There was XRCC 2 gene C41657T and G4234C polymorphism in north Chinese Han population. The genotype and allelotype distributions of the XRCC 2 C41657T and G4234C SNPs in the nonsmall cell lung cancer patients were not significantly different from those of the controls (all P

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